The blues dispatched Championship side Preston with relative ease last night, thanks to goals form Raheem Sterling, Gabriel Jesus and an own goal from Ryan Ledsan. Meanwhile the Saints beat south coast rivals Portsmouth 4-0 at Fratton Park.
Elsewhere, Aston Villa host Wolves and Watford will travel to Everton. Burton Albion, who were dispatched in ruthless fashion by City last season will host Leicester City while Chelsea host Manchester United, who edged past League One Rochdale on penalties.
The matches will be played in the week commencing 28th October.