The game will be a repeat of the 2013 FA Cup final, which Wigan won 1-0, but hopefully City can make amends at the DW Stadium.
Paul Cook’s side are currently top of League One, two points clear of Shrewsbury Town having played a game less.
Wigan have already claimed two Premier League scalps in the competition so far. They knocked out West Ham in the fourth round, beating the Hammers 2-0.
They also defeated Bournemouth 3-0 in the third round, in a replay, after a 0-0 draw at the Vitality Stadium.
Here’s a look at the draw in full:
Sheffield Wednesday v Notts County or Swansea
West Brom v Southampton
Chelsea v Hull
Leicester City v Sheffield United
Huddersfield or Birmingham v Manchester United
Brighton v Coventry
Millwall or Rochdale v Newport or Tottenham
Wigan v Manchester City
The ties are due to take place over the weekend of the 17-18 February 2018.
There’s no real standout tie with all the big teams left in the competition managing to avoid each other.
The draw also means there should be a few underdogs in the quarter-finals which might make things interesting.