Pep Guardiola and José Mourinho have disappointed in the current campaign, unable to lead their teams to a major title, although the United boss has already won the EFL Cup and could take the Europa League trophy this season. Both managers have had to deal with problems in their teams, especially when it comes to injuries.
It has been very hard for both Guardiola and Mourinho to name the same starting lineup in consecutive matches, and the number of physical problems their players have faced is a big one. Both City and United will play Thursday's Derby missing important players.
The Sky Blues are likely to miss playmaker David Silva, who injured his knee in the FA Cup semi-final against Arsenal and is unlikely to start or even make the bench against United. Gabriel Jesus is making progress and could make the bench for the first time after a foot injury, but the Brazilian is still in doubt. John Stones and Bacary Sagna are racing against the clock to return, but are also likely to miss out.
The Red Devils will miss three key players: defender Marcos Rojo is out for the season with a serious injury, and Zlatan Ibrahimovic may never play for United again after bad knee injury. Paul Pogba has also been ruled out with a muscle problem, and the team is short on defenders with Chris Smalling and Phil Jones also not playing. Juan Mata is out as well.
Here's the full list of injuries for the Manchester Derby. No players are suspended: