Joleon Lescott suffered a hamstring injury in the warm-up of the 2-1 win over Fulham and will have a scan to determine the extent of the problem.
And the defender looks set to miss out on the visit of Everton in what would have been his first game against his former club since a controversial £22m move from Goodison Park.
City boss Roberto Mancini said Lescott will have the scan before the crucial clash on Wednesday.
A big shame given Lescott's recent form and another injury in a season that has seen us lose an awful lot of players at various times.
Since returning to the side following a lengthy spell out, Lescott struck up a good partnership with Vincent Kompany, although interestingly, he was set to line up at left back against Fulham with Kolo Toure returning to the side.
Fortunately we are well served in defence and we were able to absorb the loss of Lescott. The hope though is that the scan is positive and is only a minor injury rather than a tear which would rule him out for the most part of the remainder of the season, crucial not only for our hopes but also Lescott's of making England's world cup squad.