Captain Kolo Toure will play at Wolves on Monday night.
The central defender will lead the side out at Molineux before heading off to Angola for the African Cup of Nations.
Ivory Coast stalwart Toure will though fly out for the tournament before the FA Cup tie at Middlesbrough on Saturday.
"Kolo will be in the team at Wolves," confirmed boss Roberto Mancini who is still wrestling with a miserably long injury list. "But it will be too early for many of the other injured players to return."